Deficiency in ST6GAL1, one of the two α2,6-sialyltransferases, has only a minor effect on the pathogenesis of prion disease

Deficiency in ST6GAL1, one of the two α2,6-sialyltransferases, has only a minor effect on the pathogenesis of prion disease

Prion diseases are a group of fatal neurodegenerative diseases caused by misfolding of the normal cellular form of the prion protein or PrPC, into a disease-associated self-replicating state or PrPSc. PrPC and PrPSc are posttranslationally modified with N-linked glycans, in which the terminal positi...

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Bibliographic Details
Main Authors: Natallia Makarava, Elizaveta Katorcha, Jennifer Chen-Yu Chang, Joseph T. Y. Lau, Ilia V. Baskakov
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Molecular Biosciences
Subjects:
prion
prion diseases
N-glycosylation
sialic acid
sialyltransferases
ST6GAL1
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.1058602/full

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https://www.frontiersin.org/articles/10.3389/fmolb.2022.1058602/full

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