Structural basis for arginine glycosylation of host substrates by bacterial effector proteins

Structural basis for arginine glycosylation of host substrates by bacterial effector proteins

The type III secretion system effectors NleB and SseK are glycosyltransferases (GT) that specifically glycosylate arginine residues. Here the authors provide insights into their mechanism by combining X-ray crystallography, NMR, enzyme kinetics measurements, molecular dynamics simulations and in viv...

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Bibliographic Details
Main Authors: Jun Bae Park, Young Hun Kim, Youngki Yoo, Juyeon Kim, Sung-Hoon Jun, Jin Won Cho, Samir El Qaidi, Samuel Walpole, Serena Monaco, Ana A. García-García, Miaomiao Wu, Michael P. Hays, Ramon Hurtado-Guerrero, Jesus Angulo, Philip R. Hardwidge, Jeon-Soo Shin, Hyun-Soo Cho
Format: Article
Language:English
Published: Nature Portfolio 2018-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06680-6

Internet

https://doi.org/10.1038/s41467-018-06680-6

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