Synthesis and SAR Analysis of Novel 4-Hydroxytamoxifen Analogues Based on Their Cytotoxic Activity and Electron-Donor Character

Synthesis and SAR Analysis of Novel 4-Hydroxytamoxifen Analogues Based on Their Cytotoxic Activity and Electron-Donor Character

Utilizing McMurry reactions of 4,4′-dihydroxybenzophenone with appropriate carbonyl compounds, a series of 4-Hydroxytamoxifen analogues were synthesized. Their cytotoxic activity was evaluated in vitro on four human malignant cell lines (MCF-7, MDA-MB 231, A2058, HT-29). It was found that some of th...

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Bibliographic Details
Main Authors: Cintia Duró, Tamás Jernei, Krisztina J. Szekeres, Győző G. Láng, Rita Oláh-Szabó, Szilvia Bősze, Ildikó Szabó, Ferenc Hudecz, Antal Csámpai
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Molecules
Subjects:
tamoxifen analogues
McMurry coupling
molecular rearrangement
cytotoxic activity
mechanism of action
redox properties
Online Access:https://www.mdpi.com/1420-3049/27/19/6758

Internet

https://www.mdpi.com/1420-3049/27/19/6758

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