A Coumarin–Imidazothiadiazole Derivative, SP11 Abrogates Tumor Growth by Targeting HSP90 and Its Client Proteins

A Coumarin–Imidazothiadiazole Derivative, SP11 Abrogates Tumor Growth by Targeting HSP90 and Its Client Proteins

Despite several treatment options for blood cancer, mortality remains high due to relapse and the disease’s aggressive nature. Elevated levels of HSP90, a molecular chaperone essential for protein folding, are associated with poor prognosis in leukemia and lymphoma. HSP90 as a target for chemotherap...

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Bibliographic Details
Main Authors: Snehal Nirgude, Shahana M. V., Febina Ravindran, Sujeet Kumar, Shivangi Sharma, Raghunandan Mahadeva, Anisha Mhatre, Subhas S. Karki, Bibha Choudhary
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Molecules
Subjects:
HSP90 inhibitor
DLA mouse tumor model
apoptosis
anticancer therapeutics
Online Access:https://www.mdpi.com/1420-3049/28/13/5226

Internet

https://www.mdpi.com/1420-3049/28/13/5226

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