Free-energy simulations reveal molecular mechanism for functional switch of a DNA helicase

Free-energy simulations reveal molecular mechanism for functional switch of a DNA helicase

Helicases play key roles in genome maintenance, yet it remains elusive how these enzymes change conformations and how transitions between different conformational states regulate nucleic acid reshaping. Here, we developed a computational technique combining structural bioinformatics approaches and a...

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Bibliographic Details
Main Authors: Wen Ma, Kevin D Whitley, Yann R Chemla, Zaida Luthey-Schulten, Klaus Schulten
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-04-01
Series:eLife
Subjects:
molecular dynamics
free energy landscape
structural bioinformatics
conformational transition
helicase
single molecule
Online Access:https://elifesciences.org/articles/34186

Internet

https://elifesciences.org/articles/34186

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