Motor Deficits and Cerebellar Atrophy in Elovl5 Knock Out Mice

Motor Deficits and Cerebellar Atrophy in Elovl5 Knock Out Mice

Spino-Cerebellar-Ataxia type 38 (SCA38) is caused by missense mutations in the very long chain fatty acid elongase 5 gene, ELOVL5. The main clinical findings in this disease are ataxia, hyposmia and cerebellar atrophy. Mice in which Elovl5 has been knocked out represent a model of the loss of functi...

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Bibliographic Details
Main Authors: Eriola Hoxha, Rebecca M. C. Gabriele, Ilaria Balbo, Francesco Ravera, Linda Masante, Vanessa Zambelli, Cristian Albergo, Nico Mitro, Donatella Caruso, Eleonora Di Gregorio, Alfredo Brusco, Barbara Borroni, Filippo Tempia
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
ELOVL5
spinocerebellar ataxia type 38 (SCA38)
hyposmia
motor deficit
Purkinje cell
dendrites
Online Access:http://journal.frontiersin.org/article/10.3389/fncel.2017.00343/full

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http://journal.frontiersin.org/article/10.3389/fncel.2017.00343/full

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