Human cytomegalovirus infection triggers a paracrine senescence loop in renal epithelial cells

Abstract Human cytomegalovirus (HCMV) is an opportunistic pathogen causing severe diseases in immunosuppressed individuals. To replicate its double-stranded DNA genome, HCMV induces profound changes in cellular homeostasis that may resemble senescence. However, it remains to be determined whether HC...

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Автори: Stefano Raviola, Gloria Griffante, Andrea Iannucci, Shikha Chandel, Irene Lo Cigno, Davide Lacarbonara, Valeria Caneparo, Selina Pasquero, Francesco Favero, Davide Corà, Elena Trisolini, Renzo Boldorini, Vincenzo Cantaluppi, Santo Landolfo, Marisa Gariglio, Marco De Andrea
Формат: Стаття
Мова:English
Опубліковано: Nature Portfolio 2024-03-01
Серія:Communications Biology
Онлайн доступ:https://doi.org/10.1038/s42003-024-05957-5