Overexpression of FcεRI on Bone Marrow Mast Cells, but Not MRGPRX2, in Clonal Mast Cell Disorders With Wasp Venom Anaphylaxis

Overexpression of FcεRI on Bone Marrow Mast Cells, but Not MRGPRX2, in Clonal Mast Cell Disorders With Wasp Venom Anaphylaxis

BackgroundUncertainties remain about the molecular mechanisms governing clonal mast cell disorders (CMCD) and anaphylaxis.ObjectiveThis study aims at comparing the burden, phenotype and behavior of mast cells (MCs) and basophils in patients with CMCD with wasp venom anaphylaxis (CMCD/WVA+), CMCD pat...

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Bibliographic Details
Main Authors: Jessy Elst, Leander P. De Puysseleyr, Didier G. Ebo, Margaretha A. Faber, Athina L. Van Gasse, Marie-Line M. van der Poorten, Ine I. Decuyper, Chris H. Bridts, Christel Mertens, Michel Van Houdt, Margo M. Hagendorens, Luc S. De Clerck, Anke Verlinden, Katrien Vermeulen, Marie-Berthe Maes, Zwi N. Berneman, Peter Valent, Vito Sabato
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Immunology
Subjects:
human mast cell
mastocytosis
clonal mast cell disorder
MRGPRX2
FcεRI
flow cytometry
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.835618/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.835618/full

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