The Evolution of Imprinted microRNAs and Their RNA Targets

Mammalian genomes contain many imprinted microRNAs. When an imprinted miRNA targets an unimprinted mRNA their interaction may have different fitness consequences for the loci encoding the miRNA and mRNA. In one possible outcome, the mRNA sequence evolves to evade regulation by the miRNA by a simple...

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Bibliographic Details
Main Authors: David Haig, Avantika Mainieri
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Genes
Subjects:
Online Access:https://www.mdpi.com/2073-4425/11/9/1038