Mechanisms of length-dependent recognition of viral double-stranded RNA by RIG-I

Mechanisms of length-dependent recognition of viral double-stranded RNA by RIG-I

Abstract Retinoic acid-inducible gene I (RIG-I) is the most front-line cytoplasmic viral RNA sensor and induces antiviral immune responses. RIG-I recognizes short double-stranded (dsRNA) (< 500 bp), but not long dsRNA (> 500 bp) to trigger antiviral signaling. Since RIG-I is capable of binding...

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Bibliographic Details
Main Authors: Jung Hyun Im, Ivana Duic, Shige H. Yoshimura, Koji Onomoto, Mitsutoshi Yoneyama, Hiroki Kato, Takashi Fujita
Format: Article
Language:English
Published: Nature Portfolio 2023-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-33208-w

Internet

https://doi.org/10.1038/s41598-023-33208-w

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