Triptolide enhances carboplatin-induced apoptosis by inhibiting nucleotide excision repair (NER) activity in melanoma

Triptolide enhances carboplatin-induced apoptosis by inhibiting nucleotide excision repair (NER) activity in melanoma

Introduction: Carboplatin (CBP) is a DNA damaging drug used to treat various cancers, including advanced melanoma. Yet we still face low response rates and short survival due to resistance. Triptolide (TPL) is considered to have multifunctional antitumor effects and has been confirmed to enhance the...

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Bibliographic Details
Main Authors: Geng Wang, Hongmin Guo, Yan Ren, Weiyi Chen, Yixuan Wang, Jianing Li, Hua Liu, Jingjun Xing, Yanru Zhang, Na Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Pharmacology
Subjects:
melanoma
triptolide
carboplatin
nucleotide excision repair (NER)
DNA damage
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1157433/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1157433/full

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