Modular automated microfluidic cell culture platform reduces glycolytic stress in cerebral cortex organoids

Abstract Organ-on-a-chip systems combine microfluidics, cell biology, and tissue engineering to culture 3D organ-specific in vitro models that recapitulate the biology and physiology of their in vivo counterparts. Here, we have developed a multiplex platform that automates the culture of individual...

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Bibliographic Details
Main Authors: Spencer T. Seiler, Gary L. Mantalas, John Selberg, Sergio Cordero, Sebastian Torres-Montoya, Pierre V. Baudin, Victoria T. Ly, Finn Amend, Liam Tran, Ryan N. Hoffman, Marco Rolandi, Richard E. Green, David Haussler, Sofie R. Salama, Mircea Teodorescu
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-20096-9