Cell-State Transitions Regulated by SLUG Are Critical for Tissue Regeneration and Tumor Initiation

Cell-State Transitions Regulated by SLUG Are Critical for Tissue Regeneration and Tumor Initiation

Perturbations in stem cell activity and differentiation can lead to developmental defects and cancer. We use an approach involving a quantitative model of cell-state transitions in vitro to gain insights into how SLUG/SNAI2, a key developmental transcription factor, modulates mammary epithelial stem...

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Bibliographic Details
Main Authors: Sarah Phillips, Aleix Prat, Maja Sedic, Theresa Proia, Ania Wronski, Sohini Mazumdar, Adam Skibinski, Stephanie H. Shirley, Charles M. Perou, Grace Gill, Piyush B. Gupta, Charlotte Kuperwasser
Format: Article
Language:English
Published: Elsevier 2014-05-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671114000873

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http://www.sciencedirect.com/science/article/pii/S2213671114000873

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