Targeting heparan sulfate-protein interactions with oligosaccharides and monoclonal antibodies

Targeting heparan sulfate-protein interactions with oligosaccharides and monoclonal antibodies

Heparan sulfate-binding proteins (HSBPs) are structurally diverse extracellular and membrane attached proteins that interact with HS under normal physiological conditions. Interactions with HS offer an additional level of control over the localization and function of HSBPs, which enables them to beh...

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Bibliographic Details
Main Authors: Miaomiao Li, Lars C. Pedersen, Ding Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Molecular Biosciences
Subjects:
heparan sulfate binding proteins
drug target
oligosaccharide
monoclonal antibody
crystallization
specificity
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2023.1194293/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2023.1194293/full

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