Multiomic analysis implicates nuclear hormone receptor signalling in clustering epilepsy

Multiomic analysis implicates nuclear hormone receptor signalling in clustering epilepsy

Abstract Clustering Epilepsy (CE) is an epileptic disorder with neurological comorbidities caused by heterozygous variants of the X chromosome gene Protocadherin 19 (PCDH19). Recent studies have implicated dysregulation of the Nuclear Hormone Receptor (NHR) pathway in CE pathogenesis. To obtain a co...

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Bibliographic Details
Main Authors: Rebekah de Nys, Clare L. van Eyk, Tarin Ritchie, Rikke S. Møller, Ingrid E. Scheffer, Carla Marini, Rudrarup Bhattacharjee, Raman Kumar, Jozef Gecz
Format: Article
Language:English
Published: Nature Publishing Group 2024-01-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-024-02783-5

Internet

https://doi.org/10.1038/s41398-024-02783-5

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