Correction of β-thalassemia mutant by base editor in human embryos

Correction of β-thalassemia mutant by base editor in human embryos

Abstract β-Thalassemia is a global health issue, caused by mutations in the HBB gene. Among these mutations, HBB −28 (A>G) mutations is one of the three most common mutations in China and Southeast Asia patients with β-thalassemia. Correcting this mutation in human embryos may prevent the disease...

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Bibliographic Details
Main Authors: Puping Liang, Chenhui Ding, Hongwei Sun, Xiaowei Xie, Yanwen Xu, Xiya Zhang, Ying Sun, Yuanyan Xiong, Wenbin Ma, Yongxiang Liu, Yali Wang, Jianpei Fang, Dan Liu, Zhou Songyang, Canquan Zhou, Junjiu Huang
Format: Article
Language:English
Published: Oxford University Press 2017-09-01
Series:Protein & Cell
Subjects:
β-thalassemia
HBB −28 (A>G)
base editor
human embryo
Online Access:http://link.springer.com/article/10.1007/s13238-017-0475-6

Internet

http://link.springer.com/article/10.1007/s13238-017-0475-6

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