Acute irradiation induces a senescence-like chromatin structure in mammalian oocytes

Acute irradiation induces a senescence-like chromatin structure in mammalian oocytes

Abstract The mechanisms leading to changes in mesoscale chromatin organization during cellular aging are unknown. Here, we used transcriptional activator-like effectors, RNA-seq and superresolution analysis to determine the effects of genotoxic stress on oocyte chromatin structure. Major satellites...

Full description

Bibliographic Details
Main Authors: Claudia Baumann, Xiangyu Zhang, Muthugapatti K. Kandasamy, Xiaohan Mei, Shiyou Chen, Kayvan F. Tehrani, Luke J. Mortensen, Wendy Watford, Ashley Lall, Rabindranath De La Fuente
Format: Article
Language:English
Published: Nature Portfolio 2023-12-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-023-05641-0

Internet

https://doi.org/10.1038/s42003-023-05641-0

Similar Items