Differences in F pocket impact on HLA I genetic associations with autoimmune diabetes

Differences in F pocket impact on HLA I genetic associations with autoimmune diabetes

IntroductionHuman leukocyte antigen (HLA) I molecules present antigenic peptides to activate CD8+ T cells. Type 1 Diabetes (T1D) is an auto-immune disease caused by aberrant activation of the CD8+ T cells that destroy insulin-producing pancreatic β cells. Some HLA I alleles were shown to increase th...

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Bibliographic Details
Main Authors: Xu Ren, A. W. Peshala Amarajeewa, M. D. Tharushika Jayasinghe, Malgorzata A. Garstka
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Immunology
Subjects:
HLA class I
antigen presentation
peptide binding
polymorphism
inflammation
autoimmune diabetes
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1342335/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1342335/full

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