Bulk and single-cell transcriptome profiling reveal necroptosis-based molecular classification, tumor microenvironment infiltration characterization, and prognosis prediction in colorectal cancer

Bulk and single-cell transcriptome profiling reveal necroptosis-based molecular classification, tumor microenvironment infiltration characterization, and prognosis prediction in colorectal cancer

Abstract Background Necroptosis is a new form of programmed cell death that is associated with cancer initiation, progression, immunity, and chemoresistance. However, the roles of necroptosis-related genes (NRGs) in colorectal cancer (CRC) have not been explored comprehensively. Methods In this stud...

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Bibliographic Details
Main Authors: Wenqin Luo, Wenqiang Xiang, Lu Gan, Ji Che, Jing Li, Yichao Wang, Lingyu Han, Ruiqi Gu, Li Ye, Renjie Wang, Xiuping Zhang, Ye Xu, Weixing Dai, Shaobo Mo, Qingguo Li, Guoxiang Cai
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Journal of Translational Medicine
Subjects:
Colorectal cancer
Necroptosis
Tumor microenvironment
Immunotherapy
Drug sensitivity
Online Access:https://doi.org/10.1186/s12967-022-03431-6

Internet

https://doi.org/10.1186/s12967-022-03431-6

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