Highly protein-loaded melt extrudates produced by small-scale ram and twin-screw extrusion - evaluation of extrusion process design on protein stability by experimental and numerical approaches

Highly protein-loaded melt extrudates produced by small-scale ram and twin-screw extrusion - evaluation of extrusion process design on protein stability by experimental and numerical approaches

Understanding of generation, extent and location of thermomechanical stress in small-scale (< 3 g) ram and twin-screw melt-extrusion is crucial for mechanistic correlations to the stability of protein particles (lysozyme and BSA) in PEG-matrices. The aim of the study was to apply and correlate ex...

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Bibliographic Details
Main Authors: Katharina Dauer, Kevin Kayser, Felix Ellwanger, Achim Overbeck, Arno Kwade, Heike P. Karbstein, Karl G. Wagner
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:International Journal of Pharmaceutics: X
Subjects:
Hot-melt extrusion
Protein formulation
Solid-state stability
Computational fluid dynamics
Numerical simulation
Online Access:http://www.sciencedirect.com/science/article/pii/S2590156723000403

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http://www.sciencedirect.com/science/article/pii/S2590156723000403

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