BMP3 inhibits TGFβ2-mediated myofibroblast differentiation during wound healing of the embryonic cornea

Abstract Often acute damage to the cornea initiates drastic tissue remodeling, resulting in fibrotic scarring that disrupts light transmission and precedes vision impairment. Very little is known about the factors that can mitigate fibrosis and promote scar-free cornea wound healing. We previously d...

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Bibliographic Details
Main Authors: James W. Spurlin, Matthew R. Garis, Peter Y. Lwigale
Format: Article
Language:English
Published: Nature Portfolio 2022-07-01
Series:npj Regenerative Medicine
Online Access:https://doi.org/10.1038/s41536-022-00232-9