P-gp expression inhibition mediates placental glucocorticoid barrier opening and fetal weight loss

P-gp expression inhibition mediates placental glucocorticoid barrier opening and fetal weight loss

Abstract Background Prenatal adverse environments can cause fetal intrauterine growth retardation (IUGR) and higher susceptibility to multiple diseases after birth, related to multi-organ development programming changes mediated by intrauterine overexposure to maternal glucocorticoids. As a glucocor...

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Bibliographic Details
Main Authors: Caiyun Ge, Dan Xu, Pengxia Yu, Man Fang, Juanjuan Guo, Yuan Qiao, Sijia Chen, Hui Wang, Yuanzhen Zhang
Format: Article
Language:English
Published: BMC 2021-12-01
Series:BMC Medicine
Subjects:
Intrauterine growth retardation
P-glycoprotein
Placental glucocorticoid barrier
Prenatal caffeine exposure
Histone acetylation
Online Access:https://doi.org/10.1186/s12916-021-02173-4

Internet

https://doi.org/10.1186/s12916-021-02173-4

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