A gain-of-function NLRP3 3′-UTR polymorphism causes miR-146a-mediated suppression of NLRP3 expression and confers protection against sepsis progression

A gain-of-function NLRP3 3′-UTR polymorphism causes miR-146a-mediated suppression of NLRP3 expression and confers protection against sepsis progression

Abstract Nucleotide-binding domain and leucine-rich repeat (LRR)-containing family protein 3 (NLRP3) regulated the maturation of inflammation-related cytokines by forming NLRP3 inflammasome, which plays pivotal roles in sepsis pathogenesis. In this study, we evaluated the genetic association of NLRP...

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Bibliographic Details
Main Authors: Furong Lu, Hongpeng Chen, Yuan Hong, Yao Lin, Lizhen Liu, Ning Wei, Qinyan Wu, Shuanglin Liao, Shuai Yang, Junbing He, Yiming Shao
Format: Article
Language:English
Published: Nature Portfolio 2021-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-92547-8

Internet

https://doi.org/10.1038/s41598-021-92547-8

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