Epimedin C Alleviates Glucocorticoid-Induced Suppression of Osteogenic Differentiation by Modulating PI3K/AKT/RUNX2 Signaling Pathway

Epimedin C Alleviates Glucocorticoid-Induced Suppression of Osteogenic Differentiation by Modulating PI3K/AKT/RUNX2 Signaling Pathway

Secondary osteoporosis is triggered mostly by glucocorticoid (GC) therapy. Dexamethasone (DEX) was reported to inhibit osteogenic differentiation in zebrafish larvae and MC3T3-E1 cells in prior research. In this research, we primarily examined the protective impacts of epimedin C on the osteogenic i...

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Bibliographic Details
Main Authors: Yongxiang Xu, Shichun Chen, Linxuan Huang, Weichao Han, Yingying Shao, Minyi Chen, Yusheng Zhang, Ruirong He, Baocheng Xie
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Pharmacology
Subjects:
epimedin C
PI3K
and AKT signaling pathways
osteoporosis
dexamethasone
osteogenic differentiation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.894832/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.894832/full

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