Comprehensive bioinformatic analyses of KRAS mutations and deciphering chromatin modification landscape of Caveolin-1 gene by lipid raft destabilization induced modulation of RAS-MAPK axis in colon cancer

Comprehensive bioinformatic analyses of KRAS mutations and deciphering chromatin modification landscape of Caveolin-1 gene by lipid raft destabilization induced modulation of RAS-MAPK axis in colon cancer

Ras signaling contributes to multiple components of cellular functions. To gain insight into the role of KRAS mutant isoforms, we bioinformatically analyzed and noticed that KRAS mutations at G12V, G12D, and G13D positions are prominent in colorectal adenoma and carcinoma. The bioinformatic analysis...

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Bibliographic Details
Main Authors: Ankan Roy, Moonmoon Deb, Niharika, Sabnam Parbin, Arunima Shilpi, Samir Kumar Patra
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:Advances in Cancer Biology - Metastasis
Subjects:
Lipid raft
KRAS mutation
RAS/MAPK signaling
CAV1
Histones modifications
Colon cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2667394022000223

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http://www.sciencedirect.com/science/article/pii/S2667394022000223

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