TSH Receptor Homodimerization in Regulation of cAMP Production in Human Thyrocytes in vitro

TSH Receptor Homodimerization in Regulation of cAMP Production in Human Thyrocytes in vitro

Thyrotropin hormone (TSH) was reported to exhibit biphasic regulation of cAMP production in human thyroid slices; specifically, upregulation at low TSH doses transitioning to inhibition at high doses. We observed this phenomenon in HEK293 cells overexpressing TSH receptors (TSHRs) but in only 25% of...

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Bibliographic Details
Main Authors: Alisa Boutin, Christine C. Krieger, Bernice Marcus-Samuels, Joanna Klubo-Gwiezdzinska, Susanne Neumann, Marvin C. Gershengorn
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Endocrinology
Subjects:
inverted U-shaped dose response curve
cAMP production
phosphoinositide signaling
thyrotropin receptor
TSHR
receptor homodimerization
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2020.00276/full

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https://www.frontiersin.org/article/10.3389/fendo.2020.00276/full

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