Hypoxia inactivates the VHL tumor suppressor through PIASy-mediated SUMO modification.

Hypoxia inactivates the VHL tumor suppressor through PIASy-mediated SUMO modification.

The hypoxic microenvironment contributes to embryonic development and tumor progression through stabilization of the potent transcriptional factor HIFalpha. In normoxia, the tumor suppressor protein VHL acts as an E3 ubiquitin ligase to target HIFalpha for proteolytic destruction. Increasing evidenc...

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Bibliographic Details
Main Authors: Qiliang Cai, Suhbash C Verma, Pankaj Kumar, Michelle Ma, Erle S Robertson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-03-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2838797?pdf=render

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http://europepmc.org/articles/PMC2838797?pdf=render

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