Cholinergic‐associated loss of hnRNP‐A/B in Alzheimer's disease impairs cortical splicing and cognitive function in mice

Cholinergic‐associated loss of hnRNP‐A/B in Alzheimer's disease impairs cortical splicing and cognitive function in mice

Abstract Genetic studies link inherited errors in RNA metabolism to familial neurodegenerative disease. Here, we report such errors and the underlying mechanism in sporadic Alzheimer's disease (AD). AD entorhinal cortices presented globally impaired exon exclusions and selective loss of the hnR...

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Bibliographic Details
Main Authors: Amit Berson, Shahar Barbash, Galit Shaltiel, Yael Goll, Geula Hanin, David S. Greenberg, Maya Ketzef, Albert J Becker, Alon Friedman, Hermona Soreq
Format: Article
Language:English
Published: Springer Nature 2012-05-01
Series:EMBO Molecular Medicine
Subjects:
alternative splicing
Alzheimer's disease
cholinergic signalling
hnRNP
RNA
Online Access:https://doi.org/10.1002/emmm.201100995

Internet

https://doi.org/10.1002/emmm.201100995

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