Indole-3-Propionic Acid, a Gut Microbiota-Derived Tryptophan Metabolite, Promotes Endothelial Dysfunction Impairing Purinergic-Induced Nitric Oxide Release in Endothelial Cells

Indole-3-Propionic Acid, a Gut Microbiota-Derived Tryptophan Metabolite, Promotes Endothelial Dysfunction Impairing Purinergic-Induced Nitric Oxide Release in Endothelial Cells

Different gut microbiota-derived metabolites influence cardiovascular function, and, among all, the role of indole-3-propionic acid (IPA), from tryptophan metabolism, shows controversial effects. The aim of this study was to evaluate its role in endothelial dysfunction. IPA effects were studied on b...

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Bibliographic Details
Main Authors: Federica Geddo, Susanna Antoniotti, Maria Pia Gallo, Giulia Querio
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:International Journal of Molecular Sciences
Subjects:
cardiometabolic health
endothelial dysfunction
gut microbiota
indole-3-propionic acid
nitric oxide
Online Access:https://www.mdpi.com/1422-0067/25/6/3389

Internet

https://www.mdpi.com/1422-0067/25/6/3389

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