USP39 stabilizes β-catenin by deubiquitination and suppressing E3 ligase TRIM26 pre-mRNA maturation to promote HCC progression

USP39 stabilizes β-catenin by deubiquitination and suppressing E3 ligase TRIM26 pre-mRNA maturation to promote HCC progression

Abstract Ubiquitin-specific protease 39(USP39) plays an important role in modulating pre-mRNA splicing and ubiquitin-proteasome dependent proteolysis as a member of conserved deubiquitylation family. Accumulating evidences prove that USP39 participates in the development of hepatocellular carcinoma...

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Bibliographic Details
Main Authors: Weiwei Wang, Yongbin Lei, Gongye Zhang, Xiaomei Li, Jiahui Yuan, Tingting Li, Wei Zhong, Yuqi Zhang, Xuemei Tan, Gang Song
Format: Article
Language:English
Published: Nature Publishing Group 2023-01-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-023-05593-7

Internet

https://doi.org/10.1038/s41419-023-05593-7

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