Enzyme-responsive polymersomes ameliorate autophagic failure in a cellular model of GM1 gangliosidosis
GM1 gangliosidosis is a lysosomal storage disorder caused by deficiency of β-galactosidase (βgal) and subsequent accumulation of GM1 ganglioside in lysosomes. One of the pathological aspects of GM1 gangliosidosis, and other storage disorders, is impaired autophagy, i.e., a reduced fusion of autophag...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Chemical Engineering |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fceng.2022.997607/full |