A Three Monoclonal Antibody Combination Potently Neutralizes Multiple Botulinum Neurotoxin Serotype E Subtypes

A Three Monoclonal Antibody Combination Potently Neutralizes Multiple Botulinum Neurotoxin Serotype E Subtypes

Human botulism is most commonly caused by botulinum neurotoxin (BoNT) serotypes A, B, and E. For this work, we sought to develop a human monoclonal antibody (mAb)-based antitoxin capable of binding and neutralizing multiple subtypes of BoNT/E. Libraries of yeast-displayed single chain Fv (scFv) anti...

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Bibliographic Details
Main Authors: Consuelo Garcia-Rodriguez, Ali Razai, Isin N. Geren, Jianlong Lou, Fraser Conrad, Wei-Hua Wen, Shauna Farr-Jones, Theresa J. Smith, Jennifer L. Brown, Janet C. Skerry, Leonard A. Smith, James D. Marks
Format: Article
Language:English
Published: MDPI AG 2018-03-01
Series:Toxins
Subjects:
botulinum neurotoxin
oligoclonal antibodies
serotype E botulism
recombinant antibodies
antibody engineering
mouse neutralization assay
botulinum antitoxin
Online Access:http://www.mdpi.com/2072-6651/10/3/105

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http://www.mdpi.com/2072-6651/10/3/105

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