A short perinuclear amphipathic α-helix in Apq12 promotes nuclear pore complex biogenesis

A short perinuclear amphipathic α-helix in Apq12 promotes nuclear pore complex biogenesis

The integral membrane protein Apq12 is an important nuclear envelope (NE)/endoplasmic reticulum (ER) modulator that cooperates with the nuclear pore complex (NPC) biogenesis factors Brl1 and Brr6. How Apq12 executes these functions is unknown. Here, we identified a short amphipathic α-helix (AαH) in...

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Bibliographic Details
Main Authors: Wanlu Zhang, Azqa Khan, Jlenia Vitale, Annett Neuner, Kerstin Rink, Christian Lüchtenborg, Britta Brügger, Thomas H. Söllner, Elmar Schiebel
Format: Article
Language:English
Published: The Royal Society 2021-11-01
Series:Open Biology
Subjects:
APQ12
BRR6
nuclear pore complex
nuclear envelope
BRL1
nuclear pore complex biogenesis
Online Access:https://royalsocietypublishing.org/doi/10.1098/rsob.210250

Internet

https://royalsocietypublishing.org/doi/10.1098/rsob.210250

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