A short perinuclear amphipathic α-helix in Apq12 promotes nuclear pore complex biogenesis
The integral membrane protein Apq12 is an important nuclear envelope (NE)/endoplasmic reticulum (ER) modulator that cooperates with the nuclear pore complex (NPC) biogenesis factors Brl1 and Brr6. How Apq12 executes these functions is unknown. Here, we identified a short amphipathic α-helix (AαH) in...
Main Authors: | , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
The Royal Society
2021-11-01
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Series: | Open Biology |
Subjects: | |
Online Access: | https://royalsocietypublishing.org/doi/10.1098/rsob.210250 |