6-Shogaol, an Active Component of Ginger, Inhibits p300 Histone Acetyltransferase Activity and Attenuates the Development of Pressure-Overload-Induced Heart Failure

6-Shogaol, an Active Component of Ginger, Inhibits p300 Histone Acetyltransferase Activity and Attenuates the Development of Pressure-Overload-Induced Heart Failure

Hypertrophic stress-induced cardiac remodeling is a compensatory mechanism associated with cardiomyocyte hypertrophy and cardiac fibrosis. Continuation of this response eventually leads to heart failure. The histone acetyltransferase p300 plays an important role in the development of heart failure,...

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Bibliographic Details
Main Authors: Yuto Kawase, Yoichi Sunagawa, Kana Shimizu, Masafumi Funamoto, Toshihide Hamabe-Horiike, Yasufumi Katanasaka, Satoshi Shimizu, Philip Hawke, Kiyoshi Mori, Maki Komiyama, Koji Hasegawa, Tatsuya Morimoto
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Nutrients
Subjects:
6-shogaol
p300
histone acetyltransferase
cardiac remodeling
heart failure
Online Access:https://www.mdpi.com/2072-6643/15/9/2232

Internet

https://www.mdpi.com/2072-6643/15/9/2232

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