A distal enhancer controls cytokine-dependent human cPLA2α gene expression[S]

A distal enhancer controls cytokine-dependent human cPLA2α gene expression[S]

Specific control of group IVA cytosolic phospholipase A2 (cPLA2α or PLA2G4A) expression modulates arachidonic acid production, thus tightly regulating the downstream effects of pro- and anti-inflammatory eicosanoids. The significance of this pathway in human disease is apparent in a range of patholo...

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Bibliographic Details
Main Authors: Justin S. Bickford, Dawn E. Beachy, Kimberly J. Newsom, Sarah J. Barilovits, John-David H. Herlihy, Xiaolei Qiu, Jewell N. Walters, Ning Li, Harry S. Nick
Format: Article
Language:English
Published: Elsevier 2013-07-01
Series:Journal of Lipid Research
Subjects:
group IVA phospholipase A2
gene regulation
c-Jun
CCAAT/enhancer-binding protein β
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752042139X

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http://www.sciencedirect.com/science/article/pii/S002222752042139X

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