CYP2C19 loss-of-function alleles predicts clinical outcomes in East Asian patients with acute myocardial infarction undergoing percutaneous coronary intervention and stenting receiving clopidogrel

CYP2C19 loss-of-function alleles predicts clinical outcomes in East Asian patients with acute myocardial infarction undergoing percutaneous coronary intervention and stenting receiving clopidogrel

BackgroundCYP2C19 loss-of-function (LOF) alleles reduce the effectiveness of clopidogrel and are associated with high rates of clinical events in patients undergoing percutaneous coronary intervention (PCI) and stenting in Northeast Asians. However, the prevalence and influence of CYP2C19 LOF allele...

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Bibliographic Details
Main Authors: Yu-Wei Chen, Yi-Ju Liao, Wei-Chun Chang, Tzu-Hung Hsiao, Ching-Heng Lin, Chiann-Yi Hsu, Tsun-Jui Liu, Wen-Lieng Lee, Yi-Ming Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
clopidogrel
coronary artery disease
CYP2C19
dual antiplatelet therapy
P2Y12 inhibitors
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2022.994184/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2022.994184/full

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