Large-scale antibody immune response mapping of splenic B cells and bone marrow plasma cells in a transgenic mouse model

Large-scale antibody immune response mapping of splenic B cells and bone marrow plasma cells in a transgenic mouse model

Molecular characterization of antibody immunity and human antibody discovery is mainly carried out using peripheral memory B cells, and occasionally plasmablasts, that express B cell receptors (BCRs) on their cell surface. Despite the importance of plasma cells (PCs) as the dominant source of circul...

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Bibliographic Details
Main Authors: Xiaoli Pan, Sheila N. López Acevedo, Camille Cuziol, Evelyn De Tavernier, Ahmed S. Fahad, Priyobarta S. Longjam, Sambasiva P. Rao, David Aguilera-Rodríguez, Mathilde Rezé, Christine A. Bricault, Matías F. Gutiérrez-González, Matheus Oliveira de Souza, Joshua M. DiNapoli, Emmanuelle Vigne, Melody A. Shahsavarian, Brandon J. DeKosky
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Immunology
Subjects:
B cell
antibody discovery
antibody repertoire analysis
yeast surface display
cytokine
spleen
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1137069/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1137069/full

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