Stromal fibroblasts mediate extracellular matrix remodeling and invasion of scirrhous gastric carcinoma cells.

Scirrhous gastric carcinoma (SGC) has the worst prognosis of all gastric cancers, owing to its rapid expansion by invasion and frequent peritoneal dissemination. Due to the increased proliferation of stromal fibroblasts (SFs) that occurs within SGC lesions and the peritoneal metastatic sites, SFs ha...

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Bibliographic Details
Main Authors: Hideki Yamaguchi, Nachi Yoshida, Miho Takanashi, Yuumi Ito, Kiyoko Fukami, Kazuyoshi Yanagihara, Masakazu Yashiro, Ryuichi Sakai
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3888433?pdf=render