Trans-acting aptazyme for conditional gene knockdown in eukaryotic cells

Trans-acting aptazyme for conditional gene knockdown in eukaryotic cells

Trans-acting hammerhead ribozyme inherits the advantages of being the smallest and best-characterized RNA-cleaving ribozyme, offering high modularity and the ability to cleave any desired sequence without the aid of any protein, as long as the target sequence contains a cleavage site. However, achie...

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Bibliographic Details
Main Authors: Shan Zhou, Meiyi Chen, Yi Yuan, Yan Xu, Qinlin Pu, Xilei Ai, Shuai Liu, Feng Du, Xin Huang, Juan Dong, Xin Cui, Zhuo Tang
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: Oligonucleotides: Therapies and Applications
hammerhead ribozyme
trans-acting
aptazyme
theophylline
gene knockdown
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253123001877

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http://www.sciencedirect.com/science/article/pii/S2162253123001877

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