Fast and Sensitive HPLC-ESI-MS/MS Method for Etoricoxib Quantification in Human Plasma and Application to Bioequivalence Study

Fast and Sensitive HPLC-ESI-MS/MS Method for Etoricoxib Quantification in Human Plasma and Application to Bioequivalence Study

Etoricoxib is a non-steroidal anti-inflammatory drug (NSAID) used to treat pain and inflammation. The objective of the current study was to develop a sensitive, fast and high-throughput HPLC-ESI-MS/MS method to measure etoricoxib levels in human plasma using a one-step methanol protein precipitation...

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Bibliographic Details
Main Authors: Gabriel Onn Kit Loh, Emily Yii Ling Wong, Yvonne Tze Fung Tan, Siew Chyee Heng, Mardiana Saaid, Kit Yee Cheah, Nurul Diyana Mohd Sali, Nair Damenthi, Sharon Shi Min Ng, Long Chiau Ming, Kok Khiang Peh
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Molecules
Subjects:
etoricoxib
etoricoxib D4
protein precipitation
high-sample throughput
human plasma
bioequivalence study
Online Access:https://www.mdpi.com/1420-3049/27/17/5706

Internet

https://www.mdpi.com/1420-3049/27/17/5706

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