Frequent occurrence of mitochondrial DNA mutations in Barrett's metaplasia without the presence of dysplasia.

Frequent occurrence of mitochondrial DNA mutations in Barrett's metaplasia without the presence of dysplasia.

BACKGROUND: Barrett's esophagus (BE) is one of the most common premalignant lesions and can progress to esophageal adenocarcinoma (EA). The numerous molecular events may play a role in the neoplastic transformation of Barrett's mucosa such as the change of DNA ploidy, p53 mutation and alte...

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Main Authors: Soong Lee, Moon-Jong Han, Ki-Sang Lee, Seung-Chul Back, David Hwang, Hwan-Young Kim, Jong-Hee Shin, Soon-Pal Suh, Dong-Wook Ryang, Hye-Ran Kim, Myung-Geun Shin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3358277?pdf=render

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http://europepmc.org/articles/PMC3358277?pdf=render

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