Recovery of Synthetic Zika Virus Based on Rio-U1 Isolate Using a Genetically Stable Two Plasmid System and cDNA Amplification

Recovery of Synthetic Zika Virus Based on Rio-U1 Isolate Using a Genetically Stable Two Plasmid System and cDNA Amplification

In 2016, the world experienced the unprecedented Zika epidemic. The ZIKV emerged as a major human pathogen due to its association with the impairment of perinatal development and Guillain–Barré syndrome. The occurrence of these severe cases of Zika points to the significance of studies for understan...

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Bibliographic Details
Main Authors: Iasmim Silva de Mello, Déberli Ruiz Fernandes, Nathália Dias Furtado, Alexandre Araújo Cunha dos Santos, Marta Pereira dos Santos, Ieda Pereira Ribeiro, Lidiane Menezes Souza Raphael, Mônica da Silva Nogueira, Stephanie Oliveira Diaz da Cruz, Adalgiza da Silva Rocha, Pedro Paulo de Abreu Manso, Marcelo Pelajo-Machado, Myrna Cristina Bonaldo
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Microbiology
Subjects:
Zika virus
infectious clone
two-plasmid system
cDNA amplification
cell infection
AG129 mouse infection
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.639655/full

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https://www.frontiersin.org/articles/10.3389/fmicb.2021.639655/full

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