The Catalytic Domain of Neuropathy Target Esterase Influences Lipid Droplet Biogenesis and Lipid Metabolism in Human Neuroblastoma Cells

The Catalytic Domain of Neuropathy Target Esterase Influences Lipid Droplet Biogenesis and Lipid Metabolism in Human Neuroblastoma Cells

As an endoplasmic reticulum (ER)-anchored phospholipase, neuropathy target esterase (NTE) catalyzes the deacylation of lysophosphatidylcholine (LPC) and phosphatidylcholine (PC). The catalytic domain of NTE (NEST) exhibits comparable activity to NTE and binds to lipid droplets (LD). In the current s...

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Bibliographic Details
Main Authors: Lin He, Feifei Huang, Yu Wang, Yijun Wu, Li Xu, Pingan Chang
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Metabolites
Subjects:
lipid droplet
endoplasmic reticulum
lipid metabolite
neuropathy target esterase
catalytic domain
Online Access:https://www.mdpi.com/2218-1989/12/7/637

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https://www.mdpi.com/2218-1989/12/7/637

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