Gene methylation of CADM1 and MAL identified as a biomarker of high grade anal intraepithelial neoplasia

Abstract Human papillomavirus (HPV) is detected in up to 96% of anal squamous cell cancers, where screening programs needed. However, the best methodology is still undetermined. Host DNA methylation markers CADM1, MAL and miR124 have been identified in cervical disease, but not anal disease. Anal sw...

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Bibliographic Details
Main Authors: Samuel Phillips, Kahli Cassells, Suzanne M. Garland, Dorothy A. Machalek, Jennifer M. Roberts, David J. Templeton, Fengyi Jin, I. Mary Poynten, Richard J. Hillman, Andrew E. Grulich, Gerald L. Murray, Sepehr N. Tabrizi, Monica Molano, Alyssa M. Cornall, SPANC team
Format: Article
Language:English
Published: Nature Portfolio 2022-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-07258-5