Gene methylation of CADM1 and MAL identified as a biomarker of high grade anal intraepithelial neoplasia

Gene methylation of CADM1 and MAL identified as a biomarker of high grade anal intraepithelial neoplasia

Abstract Human papillomavirus (HPV) is detected in up to 96% of anal squamous cell cancers, where screening programs needed. However, the best methodology is still undetermined. Host DNA methylation markers CADM1, MAL and miR124 have been identified in cervical disease, but not anal disease. Anal sw...

Full description

Bibliographic Details
Main Authors:	Samuel Phillips, Kahli Cassells, Suzanne M. Garland, Dorothy A. Machalek, Jennifer M. Roberts, David J. Templeton, Fengyi Jin, I. Mary Poynten, Richard J. Hillman, Andrew E. Grulich, Gerald L. Murray, Sepehr N. Tabrizi, Monica Molano, Alyssa M. Cornall, SPANC team
Format:	Article
Language:	English
Published:	Nature Portfolio 2022-03-01
Series:	Scientific Reports
Online Access:	https://doi.org/10.1038/s41598-022-07258-5

Similar Items

CpG Methylation Analysis of HPV16 in Laser Capture Microdissected Archival Tissue and Whole Tissue Sections from High Grade Anal Squamous Intraepithelial Lesions: A Potential Disease Biomarker.
by: Monica Molano, et al.
Published: (2016-01-01)

Laser capture microdissection-identified HPV genotypes associated with intra-anal high and low-grade intraepithelial lesions
by: Jennifer M. Roberts, et al.
Published: (2018-06-01)

Prevalence and risk factors associated with high-grade anal squamous intraepithelial lesions (HSIL)-AIN2 and HSIL-AIN3 in homosexual men
by: Dorothy A. Machalek, et al.
Published: (2016-12-01)

Vaccine-preventable anal human papillomavirus in Australian gay and bisexual men
by: I. Mary Poynten, et al.
Published: (2017-06-01)

Correlation between HPV16 positivity on anal swab and biopsy-confirmed HSIL caused by HPV16 in the study of the prevention of anal cancer (SPANC)
by: Jennifer M. Roberts, et al.
Published: (2018-06-01)

Development of a touchdown droplet digital PCR assay for the detection and quantitation of human papillomavirus 16 and 18 from self-collected anal samples
by: Gholamreza Haqshenas, et al.
Published: (2023-12-01)

Anal Intraepithelial Neoplasia: Precursor of Anal Squamous Cell Carcinoma
by: Taku Sakamoto, et al.
Published: (2022-04-01)

Papulomatosis bowenoide: Una neoplasia intraepitelial anal Bowenoid papulosis: An anal intraepithelial neoplasia
by: J. S. Baudet, et al.
Published: (2009-06-01)

Ki-67 expression in anal intraepithelial neoplasia in AIDS
by: Edenilson Eduardo Calore, et al.
Published: (2001-05-01)

Any condomless anal intercourse is no longer an accurate measure of HIV sexual risk behaviour in gay and other men who have sex with men
by: Fengyi eJin, et al.
Published: (2015-02-01)

Combined Liquid Biopsy Methylation Analysis of CADM1 and MAL in Cervical Cancer Patients
by: Markus Leffers, et al.
Published: (2022-08-01)

Learning discriminative classification models for grading anal intraepithelial neoplasia
by: Kainz Philipp, et al.
Published: (2016-09-01)

Anal cytological abnormalities and human papilloma virus in kidney transplant recipients
by: Richard Hillman, et al.
Published: (2018-06-01)

Awareness and knowledge of anal cancer in a community-recruited sample targeting people with HIV and gay/bisexual men
by: Richard Hillman, et al.
Published: (2018-06-01)

Cost-effectiveness of screening and treating anal pre-cancerous lesions among gay, bisexual and other men who have sex with men living with HIVResearch in context
by: Qinglu Cheng, et al.
Published: (2023-03-01)

Cytology-based Screening for Anal Intraepithelial Neoplasia in Immunocompetent Brazilian Women with a History of High-Grade Cervical Intraepithelial Neoplasia or Cancer
by: Vivian de Oliveira Rodrigues Brum, et al.
Published: (2022-08-01)

HPV genotype-specific concordance between EuroArray HPV, Anyplex II HPV28 and Linear Array HPV Genotyping test in Australian cervical samples
by: Alyssa M. Cornall, et al.
Published: (2017-12-01)

Natural History of Anal HPV Infection in Women Treated for Cervical Intraepithelial Neoplasia
by: Marta del Pino, et al.
Published: (2023-02-01)

Anal Cancer and Anal Intraepithelial Neoplasia Risk among Patients Treated for HPV-Related Gynecological Diseases—A Systematic Review
by: Michał Brzeziński, et al.
Published: (2023-06-01)

Analytical validation and diagnostic performance of the ASCL1/ZNF582 methylation test for detection of high-grade anal intraepithelial neoplasia and anal cancer
by: Kirsten Rozemeijer, et al.
Published: (2024-06-01)

Is screening for anal squamous intraepithelial lesions in women with genital human papillomavirus intraepithelial lesions necessary?
by: Francisco Eugênio de Vasconcelos Filho, et al.
Published: (2022-03-01)

Initial experience with topical fluorouracil (5-FU) for treatment of anal intraepithelial neoplasia (AIN) in HIV-positive patients
by: Aboulafia David M, et al.
Published: (2010-10-01)

Raman spectroscopy (RESpect) for anal intraepithelial neoplasia (AIN) lesions from HIV-serodiscordant couples
by: Robert Oda, et al.
Published: (2018-06-01)

P16 and Ki67 Immunostains Decrease Intra- and Interobserver Variability in the Diagnosis and Grading of Anal Intraepithelial Neoplasia (AIN)
by: Ann E. Walts M.D., et al.
Published: (2008-01-01)

HPV infection and intraepithelial lesions from the anal region: how to diagnose?
by: Newton Sérgio de Carvalho, et al.

HPV infection and intraepithelial lesions from the anal region: how to diagnose?
by: Newton Sérgio de Carvalho, PhD, et al.
Published: (2011-09-01)

Biomarker P16 Predicts Progression Risk of Anal Low-grade Squamous Intraepithelial Lesions
by: Yuxin Liu, M.D. Ph.D., et al.
Published: (2018-06-01)

Persistence of anal squamous intraepithelial lesions and anal HPV infection in HIV-infected patientsdespite immune restoration under cART
by: Tartour E, et al.
Published: (2010-10-01)

A phase I study of intra-anal artesunate (suppositories) to treat anal high-grade squamous intraepithelial lesions
by: Sandy Hwang Fang, et al.
Published: (2023-01-01)

Squamous intraepithelial lesions of the anal squamocolumnar junction: Histopathological classification and HPV genotyping
by: Omar Clavero, et al.
Published: (2017-06-01)

Abnormal anal cytology risk in women with known genital squamous intraepithelial lesion
by: Maria do Socorro Nobre, et al.
Published: (2016-05-01)

DNA Methylation Analysis to predict Regression of high-grade anal Intraepithelial Neoplasia in HIV+ men (MARINE): a cohort study protocol
by: Henry J C de Vries, et al.
Published: (2022-08-01)

Replication and characterization of CADM2 and MSRA genes on human behavior
by: Brian Boutwell, et al.
Published: (2017-07-01)

Analysis of the key ligand receptor CADM1_CADM1 in the regulation of thyroid cancer based on scRNA-seq and bulk RNA-seq data
by: Hui He, et al.
Published: (2022-11-01)

Ablation Outcomes for HIV-Infected and Uninfected Patients with Anal High-grade Squamous Intraepithelial Lesions (HSIL)
by: Yuxin Liu, M.D. Ph.D., et al.
Published: (2018-06-01)

Cadm2 regulates body weight and energy homeostasis in mice
by: Xin Yan, et al.
Published: (2018-02-01)

Corneal melt in conjunctival intraepithelial neoplasia
by: Nichelle Warren, et al.
Published: (2020-09-01)

Provider preferences for anal cancer prevention screening: Results of the International Anal Neoplasia Society survey
by: Rosalyn E. Plotzker, et al.
Published: (2022-06-01)

Comprehensive treatment of cervical intraepithelial neoplasia
by: Liana S. Mkrtchian, et al.
Published: (2021-03-01)

Determinants of high-grade anal intraepithelial lesions in HIV-positive men having sex with men
by: Isabelle Etienney, et al.
Published: (2018-06-01)