Nimbolide targeting SIRT1 mitigates intervertebral disc degeneration by reprogramming cholesterol metabolism and inhibiting inflammatory signaling

Nimbolide targeting SIRT1 mitigates intervertebral disc degeneration by reprogramming cholesterol metabolism and inhibiting inflammatory signaling

Inflammation, abnormal cholesterol metabolism, and macrophage infiltration are involved in the destruction of the extracellular matrix of the nucleus pulposus (NP), culminating in intervertebral disc degeneration (IDD). Whether nimbolide (Nim), a natural extract, can alleviate IDD is unclear. In thi...

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Bibliographic Details
Main Authors: Yun Teng, Yixue Huang, Hao Yu, Cenhao Wu, Qi Yan, Yingjie Wang, Ming Yang, Haifeng Xie, Tianyi Wu, Huilin Yang, Jun Zou
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Nimbolide
SIRT1
Intervertebral disc degeneration
Nucleus pulposus
Macrophage polarization
Cholesterol
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383523000655

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http://www.sciencedirect.com/science/article/pii/S2211383523000655

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