The Postulated Hepatotoxic Metabolite of Methimazole Causes Mitochondrial Dysfunction and Energy Metabolism Disturbances in Liver

The Postulated Hepatotoxic Metabolite of Methimazole Causes Mitochondrial Dysfunction and Energy Metabolism Disturbances in Liver

Background: Although several cases of methimazole-induced liver injury are reported, but there is no clear idea on the mechanism of methimazole hepatotoxicity. N-methyl thiourea (NMT) is a postulated hepatotoxic metabolite for methimazole. The current investigation was designed to evaluate the effec...

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Bibliographic Details
Main Author: Hossein Niknahad 1,2, Akram Jamshidzadeh 1,2, Reza Heidari 1 * , Narges Abdoli 3, Mohammad Mehdi Ommati 4, Faezeh Jafari 2, Mahdi Zarei 2, Behnam Asadi 2
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2016-12-01
Series:Pharmaceutical Sciences
Subjects:
Hepatic injury
Antithyroids hepatotoxicity
Mitochondrial dysfunction
Endocrinology
Drug-induced liver Injury (DILI)
Online Access:http://journals.tbzmed.ac.ir/PHARM/Abstract/PHARM_1557_20160823084027

Internet

http://journals.tbzmed.ac.ir/PHARM/Abstract/PHARM_1557_20160823084027

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