Oncogenic KRAS, Mucin 4, and Activin A‐Mediated Fibroblast Activation Cooperate for PanIN Initiation

Oncogenic KRAS, Mucin 4, and Activin A‐Mediated Fibroblast Activation Cooperate for PanIN Initiation

Abstract Over 90% of patients with pancreatic ductal adenocarcinoma (PDAC) have oncogenic KRAS mutations. Nevertheless, mutated KRAS alone is insufficient to initiate pancreatic intraepithelial neoplasia (PanIN), the precursor of PDAC. The identities of the other factors/events required to drive Pan...

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Bibliographic Details
Main Authors: Chun‐Mei Hu, Chien‐Chang Huang, Min‐Fen Hsu, Hung‐Jen Chien, Pei‐Jung Wu, Yi‐Ing Chen, Yung‐Ming Jeng, Shiue‐Cheng Tang, Mei‐Hsin Chung, Chia‐Ning Shen, Ming‐Chu Chang, Yu‐Ting Chang, Yu‐Wen Tien, Wen‐Hwa Lee
Format: Article
Language:English
Published: Wiley 2023-12-01
Series:Advanced Science
Subjects:
αSMA+ fibroblast
activin A
PanIN
Kras
Muc4
Online Access:https://doi.org/10.1002/advs.202301240

Internet

https://doi.org/10.1002/advs.202301240

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