Redox and metal profiles in human coronary endothelial and smooth muscle cells under hyperoxia, physiological normoxia and hypoxia: Effects of NRF2 signaling on intracellular zinc

Zinc is an important component of cellular antioxidant defenses and dysregulation of zinc homeostasis is a risk factor for coronary heart disease and ischemia/reperfusion injury. Intracellular homeostasis of metals, such as zinc, iron and calcium are interrelated with cellular responses to oxidative...

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Bibliographic Details
Main Authors: Matthew J. Smith, Fan Yang, Alexander Griffiths, Alexander Morrell, Sarah J. Chapple, Richard C.M. Siow, Theodora Stewart, Wolfgang Maret, Giovanni E. Mann
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Redox Biology
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723001131